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Abstract

The coumarin scaffold was combined with nitrogen containing heteroatom molecule known as pyrazoline to increase its biological activity, and it demonstrated a wide range of activity. The study involved the synthesis of a new compound by condensation method, and the structural structures of the prepared compounds were characterized using spectroscopic and analytical studies FT-IR, 1H-NMR,13CNMR, and mass spectrometry, through which it was proven that pyrazoline ring through the appearance of protons of the methylene group in different coupling constants. On the other hand, the proton of C11’, adapts to two different adjacent angles for the two protons of the methylene group, so the coupling constant of the protons adjacent to each other is different, and the bidirectional angle between the protons can be related to the karplus relationship with the adjacent proton coupling constant. The biological activity of the prepared compounds was studied using the principle of ABTS•+ assay depended on the generation of the blue/green ABTS•+ chromophore by the reaction between ABTS and potassium persulfate at about 734 nm, as the results of its effectiveness showed the results show that coumarin-pyrazoline derivatives are characterized by high antioxidant activity that is superior to ascorbic acid, especially the dimethylamine derivative.

Keywords

ABTS assay, Antioxidants compounds, Ascorbic acid, Coumarin- pyrazoline derivatives, Hybrid coumarin

Subject Area

Chemistry

First Page

16

Last Page

35

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Receive Date

4-20-2023

Revise Date

10-23-2023

Accept Date

10-25-2023

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