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Abstract

The biomarker significance of chemokine (Cartilage Oligomeric Matrix Protein) was evaluated in the sera of 80 rheumatoid arthritis (RA) patients and 40 control men and women. A test ELISA kit was used in the Human Reader HS apparatus to measure the serum COMP, CRP, and RF. The Nihon Kohden Europes (MEK-6550K) analyzer apparatus was used for the testing of Complete Blood Count and the erythrocyte sedimentation rate (ESR), The Westergren device was used in this evaluation. The results demonstrated that COMP, CRP, RF, and ESR showed a significantly increased median in RA patients compared to control (COMP:104.79±1.95 vs. 47.79±1.34 ng/ml; CRP: 2442.09±172.32 vs. 1271.41±35.14 pg/ml; RF: 0.92±0.03 vs. 0.34±0.024 ng/ml; ESR: 33.81±2.52 vs. 15.53±1.13 MM/H). Binary logistic regression analysis revealed that COMP was a significant predictor of RA. The ROC curve analysis also revealed that COMP recorded an area under the curve of 1.00 in RA patients. In conclusion, serum COMP is a reliable diagnostic parameter that may accurately distinguish between those with active RA and control individuals.

Keywords

Complete blood count, Cartilage oligomeric matrix protein, C-reactive protein, Rheumatoid factor, Rheumatoid arthritis

Subject Area

Chemistry

First Page

44

Last Page

50

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Receive Date

9-13-2023

Revise Date

1-22-2024

Accept Date

1-24-2024

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