Synthesis and Description of Some New Heterocyclic Imideis Compounds Derived from Ciprofloxacin Drug

Authors

Jinan D. Ayyash, Laboratory Department, Ministry of Health, Baghdad, IraqFollow
Sameaa J. Khammas, Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, IraqFollow

Abstract

The target of this work included synthesis of several new derivatives (B-B17) from Ciprofloxacin drug and evaluating antibacterial activities for some derivatives. The analogs were synthesized, designed, and characterized by ¹HNMR, and FTIR. The first step involved the preparation of a 2-Chloroacetyl Ciprofloxacin drug from the reaction of Ciprofloxacin with chloroacetyl chloride in the presence of triethylamine. Then, the yield B with 2-aminobenzothiazole in the presence of glacial acetic acid as a catalyst to produce derivatives (B1-B8), Potassium phthalimide or Succinimide was used to prepared (B9-B12) compounds , and the (B13-B17) compounds were synthesis from 4-acetyl ciprofloxacin (B).The antibacterial and antifungal activity showed effectiveness against Gram-positive bacteria (Staphylococcus), Gram-negative bacteria (Pseudomonas aeruginosa), and fungi (Candida Albicans).

Keywords

2-Aminobenzothiazole derivatives, Biological activities, Ciprofloxacin drug, Heterocyclic compounds, Imide derivatives

Subject Area

Chemistry

First Page

51

Last Page

62

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Receive Date

6-10-2023

Revise Date

3-15-2024

Accept Date

3-17-2024

How to Cite this Article

Ayyash, Jinan D. and Khammas, Sameaa J. (2025) "Synthesis and Description of Some New Heterocyclic Imideis Compounds Derived from Ciprofloxacin Drug," Baghdad Science Journal: Vol. 22: Iss. 1, Article 5.
DOI: 10.21123/bsj.2024.9222
Available at: https://bsj.researchcommons.org/home/vol22/iss1/5