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Abstract

[Pd(bit-dtc)2] complex was prepared by the reaction of sodium benzoisothiazol-3(2H)-dithiocarbamate (Nabit-dtc) with sodium tetrachloropalladate(II). Treatment of [Pd(bit-dtc)2] with one mole equivalent of Ph2P(CH)nPPh2 afforded complexes of the type [Pd(bit-dtc)2(Ph2(CH2)n PPh2)] in good yield: n = 1(dppm); n = 2 (dppe), n = 3 (dppp); n = 4 (dppb); n = (C5H4)2Fe (dppf). The prepared complexes were characterized by elemental analysis, I.R., 1H-{31P} and 31P-{1H} NMR spectroscopy the dithiocarbamate ligand bonded as mono dentate with Pd ion. The NMR spectroscopic data suggested that the prepared complexes have mononuclear coordination mode with diphosphines binding as chelating ligands, except dppm which behaves as bridging ligand, afforded binuclear complex. The antimicrobial activities of the newly synthesized Pd(II) complexes were evaluated against two types of bacteria, namely Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Furthermore, the complexes where n = 2, 4 and 5 were screened against pancreatic adenocarcinoma (SNU-2469), human gastric-esophageal adenocarcinoma (SK-GT-5), and healthy cell(WRL68). The complex [Pd(bit-dtc)2(dppe)] exhibited a significant activity against pancreatic adenocarcinoma of SNU-2469 cancer cells with IC50 value of 5.067 μM.

Keywords

Anticancer activity, Benzoisothiazol-3-dithiocarbamate, Mixed ligand complexes, Palladium, Phosphine

First Page

371

Last Page

378

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Receive Date

9-16-2023

Revise Date

11-10-2023

Accept Date

11-12-2023

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