Synthesis of Some New Hydrazide-Hydrazone and Heterocyclic Compounds Thiophene, Imine, Coumarin and Pyrazole Derivatives

Authors

Istabrick M. Al-Mola, Department of Pharmaceutical Chemistry, College of Pharmaceutical, University of Mosul, Mosul, IraqFollow
Ammar H. Al-Sabawi, Department of Chemistry, College of Science, University of Mosul, Mosul, IraqFollow

Abstract

A series of new thiophene, imine, coumarin and pyrazole derivatives X4-X16 were synthesized from N-(1-(4- (benzylsulfonyl)phenyl)ethylidene)-2-cyanoacetohydrazide X3 as a starting material with di erent reagents (tetralone, cyclopentanone, cycloheptanone, 2-hydroybenzaldehyde, 2-hydroxy-1-naphthaldehyde, CS2 and phenylisothiocyanate). The compound X3 was synthesized by the reaction of 4-(benzylsulfonyl)acetophenone with 2-cyanoacetohydrazide under reflux in ethanol. The structures of all synthesized compounds were confirmed by (FT-IR, 1H-NMR, and 13C-NMR).

Keywords

Coumarin, Heterocyclic compounds, Hydrazide-hydrazone, Imine, Pyrazole, Thiophene

First Page

419

Last Page

427

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Receive Date

9-11-2023

Revise Date

12-22-2023

Accept Date

12-24-2023

How to Cite this Article

Al-Mola, Istabrick M. and Al-Sabawi, Ammar H. (2025) "Synthesis of Some New Hydrazide-Hydrazone and Heterocyclic Compounds Thiophene, Imine, Coumarin and Pyrazole Derivatives," Baghdad Science Journal: Vol. 22: Iss. 2, Article 6.
DOI: https://doi.org/10.21123/bsj.2024.9395