Abstract
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. Therefore, it is critical for researchers to understand molecular biology in greater depth. In several diseases including cancer, abnormal miRNA expression has been linked to apoptosis, proliferation, differentiation, and metastasis. Many miRNAs have been studied in relation to cancer, including miR-122, miR-223, and others. Hepatitis B and C viruses are the most important global risk factors for HCC. This study is intended to test whether serum miRNAs serve as a potential biomarker for both HCC and viral infections HBV and C. The expression of miRNA in 64 serum samples was analyzed by RT-qPCR. Compared to healthy volunteers, HCC patients' sera expressed significantly lower levels of miR-122 and miR-223. Furthermore, we compared the expression of these miRNAs between early-diagnosed HCC patients and healthy controls. There was a significant difference between miR-122 expression in HCC sera and healthy volunteers' sera (0.000 and 0.253, respectively), with a P value of
Keywords
Hepatocellular carcinoma, HBV, HCV, Micro RNA-122, Micro RNA-223
Article Type
Special Issue Article
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite this Article
Al-Juboori, Saja Khudhier Essa and Al-Juboori, Shaymaa I K
(2023)
"Hepatocellular Carcinoma Prediction and early Diagnosis of Hepatitis B and C viral infection using miR-122 and miR-223 in a sample of Iraqi patients.,"
Baghdad Science Journal: Vol. 20:
Iss.
4, Article 34.
DOI: https://doi.org/10.21123/bsj.2023.9065
